In a Security Council meeting with the UN, Moscow's ambassador of the UN, Vasily Nebenzia, stated that the main goal Britain had was "to discredit and even deligitimise" Russia with "unsubstantiated accusations".
According to the UK, Russia is backing the attack, though Moscow rejects any liability.
The UN representative for Britain, Karen Pierce, has declared that the actions of the UK "stand up to any scrutiny".
Pierce likened Moscow's requests to participate in the investigation to an artist inquiring into who created the fire that they'd made.
Sergei Skripal, the former Russian spy, and his daughter, Yulia, were discovered unconscious in Salisbury on the 4th March.
Having released a statement saying that her "strength is growing daily", Skripal, 33, seems to be steadily recovering in the hospital she has been placed.
Skripal's parent, her 66 year-old father, is stable, yet, still critically ill.
It has been exposed that a couple of guinea pigs have been found dead in Mr Skripal's house, in addition to a cat in poor condition, which vets chose to put down
Meanwhile it has emerged that two guinea pigs were found dead at Mr Skripal's home, alongside a cat in poor health, which vets decided should be put down.
"horrific and unsubstantiated"
Stating that Britain had "legitimate questions" to answer, Moscow spoke to the special meeting of the New York Security Council to talk about the attack.
Suggesting that the UK have been holding a "propaganda war" against Russia, Nebenzia has stated that accusations have been "horrific and unsubstantiated".
Nebenzia has also said that Novichock, the collection of nerve agents used in the poisoning, are "not copyrighted by Russia, in spite of the obviously Russian name" and has received further development in many other countries.
"It's some sort of theatre of the absurd. Couldn't you come up with a better fake story?" he asked.
In Mr Nebenezia's statement to the 15-member council, he asked why Russia would get rid of an individual using a "dangerous and highly public" methodology.
The utilisation of chemicals was juxtaposed with the "hundred of clever ways of killing someone" displayed in the British series Midsomer Murders.
In response, Karen Pierce, British Ambassador to the UN, accused Russia of aspiring to "undermine the international institutions that have kept us safe since the Second World War".
It was suggested by Pierce that Russia appeared suspicious for several reasons. saying that it had "a record of conducting state-sponsored assassinations" and that it "views defectors as suitable targets for assassination".
Pierce said to delegates that Russia's appeal to visit Skripal had been passed on and "we await her response".
"Skripal's own wishes need to be taken into account," added Ms Pierce.
Sir Malcolm Rifkind, former foreign secretary, told BBC Radio 4's Today programme that what Russia commented was a "classic Russian attempt to obfuscate".
The secretary said: "They are in a very serious position because it's not just the UK that has taken action against them. In an unprecedented way, that did not even happen in the Cold War, 29 countries have withdrawn their diplomats."
The secretary had also said that the UK had shared "highly classifies information" with the other countries which was equally as "unprecedented",